June 27, 2000
8:00 am - 5:00 pm
Doubletree Hotel (Plaza II Room), 1750 Rockville Pike, Rockville, MD
Co-chairs: Jerry Frankenheim, PhD and Minda Lynch, PhD
Division of Neuroscience and Behavioral Research
National Institute on Drug Abuse
| 8:00 am | Complimentary continental breakfast |
| Introductions | |
| 8:30 am |
Alan I. Leshner, PhD, Director, NIDA Timothy P. Condon, PhD, Associate Director, NIDA Stephen R. Zukin, MD, Associate Director, Div of Treatment Research & Development, NIDA |
| Session 1 - GHB abuse: Trends, trafficking, and clinical outcomes | |
| 9:00 am | James Hall, BA (Up Front Drug Information Center, Miami) Liquid X via the Internet: Surveillance and Observed Trends in Abuse of GHB-Related Drugs |
| 9:45 am | Special Agent Robert P. Mecir (Bureau of Narcotic Enforcement, San Jose Regional Office, California Dept of Justice) GHB - Manufacturing, Distribution, Use, and the Law |
| 10:30 am | Brief intermission |
| 10:45 am | Karen Miotto, MD (UCLA Dept of Psychiatry & Biobehavioral Sciences) Clinical Management of GHB Tolerance, Dependence, and Withdrawal |
| Session 2 - GHB biochemistry, pharmacology, pathophysiology, and therapeutic potential | |
| 11:30 am | Michel Maitre, MD, PhD (Biochemistry Institute, Strasbourg, France) Physiological versus Pharmacological Mode of Action of GHB |
| 12:15 pm | Lunch (on your own) |
| 1:15 pm | O. Carter Snead III, MD (Neurology Div, Dept of Pediatrics, U of Toronto) Are the Psychotropic Effects of GHB Mediated by a GHB-Specific or a GABA-B Receptor? |
| 2:00 pm | Prof. Gian Luigi Gessa (Dept of Neuroscience "B.B.Brodie," U of Cagliari, Italy) Mechanism of GHB Action in the Treatment of Alcoholism and |
| Dr. Giancarlo Colombo (Neuroscienze s.c.a.r.l., Cagliari, Italy) The Mechanism of Positive Reinforcing Effect of GHB | |
| 3:00 pm | Intermission |
| 3:30 pm | K. Michael Gibson, PhD, FACMG (Molecular & Medical Genetics & Pediatrics, Oregon Health Sciences U, Portland) Development, Preliminary Characterization, and Pharmacologic Rescue of a Murine Knockout Model of 4-Hydroxybutyric Aciduria |
| Session 3 - Panel/audience discussion: All about GHB | |
| 4:15 pm | Elaine E. Kaufman, PhD (Lab of Cerebral Metabolism, NIMH, NIH) Dr. Kaufman will lead the panel |
| 5:00 pm | Adjourn |
For additional information contact Dr. Frankenheim at (301) 435-1312, jfranken@nida.nih.gov.
For questions on meeting logistics, please phone Kathleen Janson at Management Assistance Corporation, (301) 468-6008, ext. 432.
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