NIDA - Research Monographs - Monograph 120: Bioavailability of Drugs to the Brain and Blood-Brain Barrier

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	Bioavailability of Drugs to the Brain and Blood-Brain Barrier

NIDA Research Monograph, Number 120 [Printed in 1992]

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Table of Contents

Introduction-----1
Jerry Frankenheim

The Basic Neurobiology of Addiction-----4
Roger M. Brown

Some Relationships Between Addiction and Drug Delivery to the Brain-----13
William H. Oldendorf

Neuroactive Peptides and Amino Acids at the Blood Brain Barrier: Possible Implications for Drug Abuse-----26
Berislav V. Zlokovic, J. Gordon McComb Lynn Perlmutter, Martin H. Weiss, and Hugh Davson

MPTP Toxicity and the "Biochemical" Blood-Brain Barrier-----43
Sami I. Harik

An Overview of the Multiple Functions of the Blood-Brain Barrier-----54
A. Lorris Betz

Formation and Differentiation of Brain Capillaries.-----73
John Laterra, Johannes E.A. Wolff, Christopher Guerin, and Gary W. Goldstein

Nonpermeable and Permeable Vessels of the Brain-----87
Milton W. Brightman and Yoshiaki Kadota

The Blood-Brain Barrier Is Not a "Barrier" for Many Drugs-----108
Joseph D. Fenstermacher

Drug Delivery to the Brain: Barrier Modification and Drug Modification Methodologies-----121
Stanley I. Rapoport

Cultured Brain Microvessel Endothelial Cells as In Vitro Models of the Blood-Brain Barrier-----138
Yoshinobu Takakura, Kenneth L. Audus, and Ronald T. Borchardt

Opioid Peptide Drug Development: Transport of Opioid Chimeric Peptides Through the Blood-Brain Barrier-----153
William M. Pardridge

Redox Approaches to Drug Delivery to the Central Nervous System-----169
Marcus E. Brewster and Nicholas Bodor

Drug Delivery to the Brain Using an Anti-Transferrin Receptor Antibody-----202
Phillip M. Friden, Lee Walus, Marjorie Taylor, Gary F. Musso, Susan A. Abelleira, Bernard Malfroy, Fariba Tehrani, Joseph B. Eckman III. Anne R. Morrow, and Ruth M. Starzyk

Permeation of the Blood-Brain Barrier for Drug Delivery to the Brain-----218
Heidi C. Horner, Kari Barbu, Frederique Bard, Deborah Hall, Mary Janatpour, Katy Manning, Janine Morales, Seth Porter, Paulette E. Seller, Laura Tanner, and Lee R. Rubin

Pathways Into, Through, and Around the Fluid-Brain Barriers-----230
Richard D. Broadwell

List of NIDA Research Monographs-----259

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