| Pilot Development and Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine |
CTN-0156 |
Development |
| Low-threshold Buprenorphine Treatment at Syringe Services Programs: a Type I Hybrid Effectiveness-implementation Trial |
CTN-0155 |
Development |
| EMS initiated Buprenorphine for Opioid Use Disorder |
CTN-0154 |
Development |
| Effects of Semaglutide and Tirzepatide on Incidence and Outcomes of Stimulant Use Disorders and Opioid Use Disorder in Real-world Populations: Target Trial Emulation Using Patient Electronic Health Records (GLP-SUD). |
CTN-0153 |
Active |
| Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the treatment of opioid use disorder: A pragmatic, multi-site, double-blind, Randomized, placebo-controlled, trial (TAB). |
CTN-0152 |
Development |
| Toward Pharmacy-Led Value Based Care Model for Buprenorphine Initiation and Management (PharmValue): Development of a Scalable Pharmacist-Led Collaborative Practice Agreement for Medication for Opioid Use Disorder |
CTN-0151 |
Active |
| Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD |
CTN-0150 |
Completed |
| Trajectories of Secondary Outcomes in CTN Trials |
CTN-0149 |
Active |
| Cocaine Craving and Use Outcomes Secondary Analysis of a Randomized Study to Test the Safety and Effectiveness of Buprenorphine in the Presence of Naltrexone for the Treatment of Cocaine Dependence |
CTN-0148 |
Completed |
| Adolescent outcomes of Post-operative opioid Exposure (APEX) (NIH HEAL Initiative) |
CTN-0146 |
Active |
| Standard versus High Dose ED-Initiated Buprenorphine Induction (NIH HEAL Initiative) |
CTN-0145 |
Active |
| Better Together: Integrating MOUD in African American Community Settings (NIH HEAL Initiative) |
CTN-0144 |
Development |
| Social Determinants of Health (SDOH); Needs and Consequences Associated with Substance Use Disorders |
CTN-0143 |
Completed |
| Towards Personalized Medicine in Medication for Opioid Use Disorder (MOUD): Analyses of Veterans Health Administration Data to Delineate Patient Characteristics Associated with Treatment Outcomes and Successful MOUD Discontinuation |
CTN-0142 |
Active |
| Health Insurance Instability and Mortality among Patients Receiving Buprenorphine Treatment for Opioid Use Disorder: Linkage of the Prescription Opioid Registry with the National Death Index |
CTN-0141 |
Completed |
| Cannabis Use among Pregnant Women with Polysubstance Use and Psychiatric Problems |
CTN-0140 |
Completed |
| Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care) (NIH HEAL Initiative) |
CTN-0139 |
Active |
| Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool |
CTN-0138 |
Active |
| Multi-Level Stigma Intervention to Improve Access to Substance Use Care with Prescribing Providers in Mental Health Settings |
CTN-0137 |
Completed |
| Medication for Opioid Use Disorder, Predictability of Retention vs. Attrition |
CTN-0136 |
Completed |
| Buprenorphine Treatment Engagement and Induction Problems Among Individuals Using Fentanyl |
CTN-0135 |
Completed |
| Buprenorphine-Precipitated Withdrawal Hotspots and Correlates |
CTN-0134 |
Completed |
| Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (NIH HEAL Initiative) |
CTN-0133 |
Completed |
| Ketamine for Methamphetamine Use Disorder Study |
CTN-0132 |
Active |
| Office-Based Methadone versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment – A Randomized Pragmatic Hybrid Effectiveness/Implementation Trial |
CTN-0131 |
Active |
| Quantifying How Cocaine Users Respond to Fentanyl Contamination in Cocaine (NIH HEAL Initiative) |
CTN-0130 |
Completed |
| The Great Plains Initiative |
CTN-0129 |
Completed |
| Adherence and Feasibility of Wearable Technologies and Ecological Momentary Assessment to Assess Autonomic Function and Negative Affect in Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0128 |
Completed |
| Engaging African American Faith-based leaders in a Substance Use Learning Collaborative |
CTN-0127 |
Completed |
| Longitudinal Follow-up of Individuals with Opioid Use Disorder |
CTN-0126 |
Active |
| Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine |
CTN-0125 |
Completed |
| Assessment and Design of a Cost-Effective Collaborative MOUD Delivery System |
CTN-0124 |
Completed |
| Facebook intervention for preventing opioid relapse among American Indian Women |
CTN-0123 |
Active |
| Comprehensive Meta-Analysis of CTN Treatment Outcomes by Race and Sex |
CTN-0122 |
Completed |
| Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders (SUD) among Hospitalized Patients |
CTN-0121 |
Active |
| R-Mist: Remote Methadone Ingestion Surveillance Trial |
CTN-0120 |
Completed |
| Impact of Social Distancing Measures, Expansion of Telemedicine for Buprenorphine Prescribing, and Health Insurance Payor on Access to Buprenorphine During the COVID-19 Pandemic |
CTN-0119 |
Completed |
| Examining the COVID-19 Public Health Emergency on Policy, Substance Use Disorder, Treatment and Resilience among American Indian and Alaska Native Communities |
CTN-0118 |
Completed |
| The Impact of COVID-19 Pandemic on Substance Use Treatment Services |
CTN-0117 |
Completed |
| Pharmacist-Integrated Model of Medication Treatment for Opioid Use Disorder |
CTN-0116 |
Completed |
| Developing an Intervention to Address Intersecting Prescription Opioid and Chronic Pain Stigma in Cancer Survivors (NIH HEAL Initiative) |
CTN-0115 |
Completed |
| Drug Repurposing for Cocaine Use Disorder (CUD) Using a Combined Strategy of Artificial Intelligence (AI)-Based Prediction and Retrospective Clinical Corroboration |
CTN-0114 |
Completed |
| Validating a DSM-5 Substance Use Disorder (SUD) Symptom Checklist in EHR Data from a Large Primary Care Sample to Support Future Pragmatic Trials and Chronic Care Management of SUDs in Primary Care |
CTN-0113 |
Completed |
| Optimal Policies to Improve Methadone Maintenance Adherence Long-Term (OPTIMMAL) |
CTN-0112 |
Completed |
| COVID-19 and Substance Misuse Case Identification using Data Science: A Retrospective Cohort Study |
CTN-0111 |
Completed |
| Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB)(NIH HEAL Initiative) |
CTN-0110 |
Completed |
| Innovative Development of Research Engagement Manual (I-DREM): Strategies to Enhance Recruitment and Retention of Black Individuals in CTN-0109 CURB-2 |
CTN-0109-A-1 |
Completed |
| Randomized, Placebo-Controlled Trial of Injectable Naltrexone and Monthly Injectable Buprenorphine for Cocaine Use Disorder (CURB-2) |
CTN-0109 |
Active |
| Transcranial Magnetic Stimulation for the Treatment of Methamphetamine/Cocaine Use Disorder |
CTN-0108 |
Completed |
| Why do patients decline buprenorphine from the emergency department? |
CTN-0107-A-1 |
Completed |
| Peer Intervention to Link Overdose survivors to Treatment (PILOT) (NIH HEAL Initiative) |
CTN-0107 |
Completed |
| Derivation and Validation of New Measurement-Based Care Tools Derived from the Brief Addiction Monitor (NIH HEAL Initiative) |
CTN-0106 |
Completed |
| Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative) |
CTN-0105 |
Completed |
| Healthcare Provider Stigma Related to the Opioid Use Epidemic and its Impact on Patient Treatment and Clinical Management |
CTN-0104 |
Completed |
| Expanding Clinical Research Training on Implementing the Evidence-based Hub and Spoke Model of Medication-Assisted Treatment for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0103 |
Completed |
| Rural Expansion of Medication Treatment for Opioid Use Disorder: Randomized Controlled Pilot Trial of Extended-release Buprenorphine vs. Sublingual Buprenorphine-naloxone in Rural Settings (NIH HEAL Initiative) |
CTN-0102-XR |
Active |
| Rural Expansion of Medication Treatment for Opioid Use Disorder: Electronic Health Record Data Collection and Analysis (NIH HEAL Initiative) |
CTN-0102-C |
Completed |
| COVID Impact on Rural Expansion of Medication Treatment for Opioid Use Disorder |
CTN-0102-A |
Completed |
| Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0102 |
Completed |
| Subthreshold Opioid Use Disorder Prevention (STOP) Trial (NIH HEAL Initiative) |
CTN-0101 |
Completed |
| Discontinuing Buprenorphine: Patient Experiences (DC-BUPE) |
CTN-0100-A-1 |
Active |
| Optimizing Retention, Duration, and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (NIH HEAL Initiative) |
CTN-0100 |
Active |
| Barriers and Facilitators to Engaging in Addiction Treatment among Black, Latino, and non-Latino White Patients Receiving ED-initiated Buprenorphine Treatment (NIH HEAL Initiative) |
CTN-0099-A-1 |
Completed |
| Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative) |
CTN-0099 |
Completed |
| Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE) (NIH HEAL Initiative) |
CTN-0098 |
Active |
| Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0097 |
Completed |
| National Medication-Assisted Treatment Survey of Substance Use Disorder Programs Serving American Indian and Alaska Native People (NIH HEAL Initiative) |
CTN-0096-A-1 |
Completed |
| Culturally Centered MAT for OUD Implementation Facilitation for Primary Care and Addiction Treatment Programs Serving American Indian/Alaska Natives (NIH HEAL Initiative) |
CTN-0096 |
Completed |
| Reducing Stigma Toward People with Opioid Use Disorder Among Primary Care Clinicians (NIH HEAL Initiative) |
CTN-0095-A-2 |
Completed |
| Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0095-A-1 |
Completed |
| Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative) |
CTN-0095 |
Completed |
| Individual Level Predictive Modeling of Opioid Use Disorder Treatment Outcome (NIH HEAL Initiative) |
CTN-0094 |
Completed |
| Validation of a Community Pharmacy-based Prescription Drug Monitoring Program Risk Screening Tool (PHARMSCREEN) (NIH HEAL Initiative) |
CTN-0093 |
Completed |
| Preventing and Identifying Opioid Use Disorder using the Six Building Blocks (6BBs) for Improving Opioid Prescription Management (NIH HEAL Initiative) |
CTN-0091 |
Completed |
| Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (NIH HEAL Initiative) |
CTN-0090 |
Completed |
| Integrating Nurse Practitioner Buprenorphine Waiver Training into Graduate Nursing Curriculum (NIH HEAL Initiative) |
CTN-0089 |
Completed |
| Better Together. Community Partnership for a Healthy Community Free from Addiction |
CTN-0088 |
Completed |
| A Foundation to Examine Reasons for Discontinuation for Buprenorphine Care in the Veterans Health Administration (NIH HEAL Initiative) |
CTN-0087 |
Completed |
| Inpatient versus Outpatient Treatment Outcomes for People with Opioid Use Disorder (NIH HEAL Initiative) |
CTN-0086 |
Completed |
| Selection Bias-Free Estimation of the Impact of Drug-Focused 12-step Mutual Help Groups (NIH HEAL Initiative) |
CTN-0085 |
Completed |
| Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder (D-TECT) (NIH HEAL Initiative) |
CTN-0084-A-2 |
Completed |
| Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality (NIH HEAL Initiative) |
CTN-0084-A-1 |
Completed |
| Developing a Prescription Opioid Registry across Diverse Health Systems (NIH HEAL Initiative) |
CTN-0084 |
Completed |
| Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services |
CTN-0083 |
Completed |
| Vaccine Readiness in People Who Use Substances In Community STI Clinics and Substance Use Intervention or Harm Reduction Programs In Eight Higher HIV Incidence Southeastern Cities |
CTN-0082-A-1 |
Completed |
| Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and MSM-Centered Community Based Organizations (CBOs) |
CTN-0082 |
Completed |
| Emergency Medicine Opioid Data Infrastructure: Key Venue to Address Opioid Morbidity and Mortality (Project CODE PRO – Capturing Opioid Use Disorder Electronically and Patient Reported Outcomes) |
CTN-0081 |
Completed |
| Improved Messaging Strategies for MOUD for Underserved Populations of Pregnant and Postpartum Individuals with OUD |
CTN-0080-A-3 |
Completed |
| Promoting Research with Mothers receiving OUD Treatment; a focus on Equity (PRoMOTE) |
CTN-0080-A-2 |
Completed |
| Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant People with Opioid Use Disorder (SUCCESS STUDY) |
CTN-0080-A-1 |
Completed |
| Medication Treatment for Opioid-dependent Expecting Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (NIH HEAL Initiative) |
CTN-0080 |
Completed |
| Ancillary Study of the Adoption and Sustainability of ED-Initiated Buprenorphine (NIH Heal Initiative) |
CTN-0079-A-1 |
Completed |
| Emergency Department Connection to Care with Buprenorphine for Opioid Use Disorder (ED-CONNECT) |
CTN-0079 |
Completed |
| Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities |
CTN-0078 |
Completed |
| Medical Cannabis Use among Primary Care Patients: Using Electronic Health Records to Study Large Populations |
CTN-0077 |
Completed |
| Clinical decision support for Opioid use disorders in Medical settings: Pilot Usability Testing in an EMR (COMPUTE) |
CTN-0076 |
Completed |
| Pharmacy Screening and Collaborative Opioid Use Disorder Care (Pharm-OUD-Care) |
CTN-0075 |
Completed |
| Primary Care Opioid Use Disorders Treatment Trial Economic Analysis Study (NIH HEAL Initiative) |
CTN-0074-A-1 |
Completed |
| Primary Care Opioid Use Disorders Treatment Trial |
CTN-0074 |
Completed |
| Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network |
CTN-0073 |
Completed |
| Patient and System-Level Factors Associated with HEDIS AOD-IET Measure Performance across Health Systems |
CTN-0072 |
Completed |
| Electronic Health Records Data Elements Research (EHR-DARE) |
CTN-0071 |
Completed |
| Interpretation and Implementation of Title 42 CFR Part 2 for Confidentiality of Patient Drug and Alcohol Use Records: NIDA CTN Stakeholder Snapshot |
CTN-0070 |
Completed |
| Opioid Use Disorder in the Emergency Department |
CTN-0069 |
Completed |
| Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder |
CTN-0068 |
Completed |
| Comparing Treatments for HIV-Positive Opioid Users in an Integrated Care Effectiveness Study (CHOICES); Scale-Up |
CTN-0067 |
Completed |
| Opioid Use Disorders in Primary Care Settings: Linking EHRs with PDMP and National Death Index Data Systems |
CTN-0066 |
Completed |
| Evaluation of Drug Screening Implementation in Primary Care |
CTN-0065 |
Completed |
| Linkage to Hepatitis C Virus Care among HIV/HCV Co-infected Substance Users |
CTN-0064 |
Completed |
| Gender Differences in the Interrelationships between Sexual Abuse, Risky Sexual Behavior, and Anxiety/Depression in Treatment Efficacy and Drug Use over Time among Individuals with Substance Use Disorders |
CTN-0063 |
Completed |
| A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements into the Electronic Health Record in Large Primary Care Settings |
CTN-0062 |
Completed |
| Kaiser Virtual Data Warehouse - Prescription Opioid Users |
CTN-0061 |
Completed |
| Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief screen/assessment tool (TAPS Tool) |
CTN-0059 |
Completed |
| Screening, Brief Intervention, and Referral to Treatment in Primary Care (SBIRT-PC): An add-on project to “Duke University CMS Innovation Award Southeastern Diabetes Initiative” |
CTN-0057 |
Completed |
| Testing and Linkage to HIV Care in China: a Cluster Randomized Trial |
CTN-0056 |
Completed |
| Comparing Treatments for HIV-Positive Opioid Users in an Integrated Care Effectiveness Study (CHOICES) |
CTN-0055 |
Completed |
| Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT) |
CTN-0054 |
Completed |
| Achieving Cannabis Cessation: Evaluating N-Acetylcysteine Treatment (ACCENT) |
CTN-0053 |
Completed |
| A Randomized Controlled Evaluation of Buspirone for Relapse-Prevention in Adults with Cocaine Dependence (BRAC) |
CTN-0052 |
Completed |
| Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT) |
CTN-0051 |
Completed |
| The START Follow-Up Study |
CTN-0050 |
Completed |
| Project HOPE: Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users |
CTN-0049 |
Completed |
| Cocaine Use Reduction with Buprenorphine (CURB) |
CTN-0048 |
Completed |
| Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED) |
CTN-0047 |
Completed |
| Smoking-Cessation and Stimulant Treatment (S-CAST): Evaluation of the Impact of Concurrent Outpatient Smoking-Cessation and Stimulant Treatment on Stimulant-Dependence Outcomes |
CTN-0046 |
Completed |
| Web-delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders |
CTN-0044 |
Completed |
| Stimulant Reduction Intervention using Dosed Exercise |
CTN-0037 |
Completed |
| HIV Rapid Testing and Counseling in Drug Abuse Treatment Programs in the U.S. |
CTN-0032 |
Completed |
| An Evaluation of Neurocognitive Function, Oxidative Damage, and their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers |
CTN-0031-A-1 |
Completed |
| Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement |
CTN-0031 |
Completed |
| Prescription Opioid Addiction Treatment Study (POATS) |
CTN-0030 |
Completed |
| A Pilot Study of Osmotic-Release Methylphenidate (OROS-MPH) in Initiating and Maintaining Abstinence in Smokers with Attention Deficit Hyperactivity Disorder (ADHD) |
CTN-0029 |
Completed |
| Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS-MPH) for Attention Deficit Hyperactivity Disorder in Adolescents with Substance Use Disorders |
CTN-0028 |
Completed |
| Starting Treatment with Agonist Replacement Therapies (START) Study |
CTN-0027 |
Completed |
| Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse |
CTN-0021 |
Completed |
| Job-Seekers Training for Patients with Drug Dependence |
CTN-0020 |
Completed |
| Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment |
CTN-0019 |
Completed |
| Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment |
CTN-0018 |
Completed |
| HIV and HCV Intervention in Drug Treatment Settings |
CTN-0017 |
Completed |
| Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment |
CTN-0016 |
Completed |
| Women's Treatment for Trauma and Substance Use Disorders |
CTN-0015 |
Completed |
| Brief Strategic Family Therapy (BSFT) for Adolescent Drug Abusers |
CTN-0014 |
Completed |
| Motivational Enhancement Therapy to Improve Treatment Utilization and Outcome in Pregnant Substance Users |
CTN-0013 |
Completed |
| Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infection, and Sexually Transmitted Infections in Substance Abuse Treatment Programs |
CTN-0012 |
Completed |
| A Feasibility Study of a Telephone Enhancement Procedure (TELE) To Improve Participation in Continuing Care Activities |
CTN-0011 |
Completed |
| Buprenorphine/Naloxone (Bup/Nx) Facilitated Rehabilitation for Heroin Addicted Adolescents/Young Adults |
CTN-0010 |
Completed |
| Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs |
CTN-0009 |
Completed |
| A Baseline for Investigating Diffusion of Innovation |
CTN-0008 |
Completed |
| Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics |
CTN-0007 |
Completed |
| Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics |
CTN-0006 |
Completed |
| Motivational Interviewing (MI) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse |
CTN-0005 |
Completed |
| MET (Motivational Enhancement Treatment) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse |
CTN-0004 |
Completed |
| Suboxone® (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules |
CTN-0003 |
Completed |
| Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Outpatient Opiate Detoxification |
CTN-0002 |
Completed |
| Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Inpatient Opiate Detoxification |
CTN-0001 |
Completed |
